Some assembly needed

Assembly of RNPs: help needed.

In 1968 the Nomura lab in Madison made an astonishing observation: when ribosomal proteins were mixed under appropriate conditions with 16S rRNA, fully functional ribosomal 30S subunits were formed. Along with the subsequent total reconstitution of 50S subunits, it was established that even entire ribosomes could be assembled in vitro from their constituents. Neither energy in the form of nucle...

Some Assembly Necessary

ODA16p, a Chlamydomonas flagellar protein needed for dynein assembly.

Dynein motors of cilia and flagella function in the context of the axoneme, a very large network of microtubules and associated proteins. To understand how dyneins assemble and attach to this network, we characterized two Chlamydomonas outer arm dynein assembly (oda) mutants at a new locus, ODA16. Both oda16 mutants display a reduced beat frequency and altered swimming behavior, similar to prev...

Potassium Channels Some Assembly Required

(Shi et al., 1996, and references therein). In the heart Many types of channels and receptors are expressed and the ear, a single-spanning transmembrane protein, in the nervous system, contributing to the complex and minK, coassembles with KvLQT1 tetramers to form a diverse functional repertoires of neurons. Regulation of delayed rectifier that plays an essential role in repolartranscription an...

Rotavirus genome replication: Some assembly required

1 Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, Virginia, United States of America, 2 Translational Biology, Medicine, and Health Graduate Program, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, United States of America, 3 Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virgin...